Metanephrine and Normetaneprine

Urinary Metanephrines
Metanephrine and normetanephrine are the 3-methoxy metabolites of epinephrine and norepinephrine, respectively. They are metabolized to vanillylmandelic acid or excreted with the urine.
Patients with pheochromocytoma or other tumours derived from neuroendocrine cells show elevated urinary levels of total Metanephrines.
As catecholamine secretion from neuroendocrine cells might show high variations urine samples collected over a period of 24 hours are used to average these fluctuations.

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