Metanephrine, Normetanephrine
Free Plasma Metanephrines

Free Plasma Metanephrines

Cells derived form neuroendocrine tumours (e.g. Pheochromcytoma) are known to produce Catecholamines which are secreted episodically via vesicles into the blood stream. But beside this a small portion of the Catecholamines is metabolized inside the cells to the corresponding Catecholamines metabolites – namely Metanephrine, Normetanephrine and 3-methoxytyramine – which are secreted at low levels continuously into the blood stream.
Recent studies and publications have shown that the quantification of these plasma free metanephrine (fMN) and plasma free normetanephrine (fNMN) is the most accurate biochemical marker for the clinical diagnosis of Pheochromocytoma and follow-up of pheochromocytoma patients.
LDN has developed enzyme immunoassays and isotopic assays for the quantitative determination of fMN and fNMN in human plasma without extraction.

The assays show the following common features:

  • speed and ease of use
  • cost-effective
  • for in-vitro diagnostic and research applications
  • wide standard ranges
  • available as ELISA and RIA (with 15 weeks shelf-life)
  • the ELISA is automatable
  • freedom from drug interferences
  • excellent correlation with HPLC and LC-MS/MS
  • single and multi parameter kits available

With this new assay LDN is now able to offer the most comprehensive panel worldwide for the measurement of PPGL-relevant parameters including:

  • Urinary Metanephrine/Normetanephrine (free and total; ELISA & RIA)
  • Plasma Metanephrine/Normetanephrine (ELISA & RIA)
  • Catecholamines in plasma and urine (ELISA & RIA)
  • Chromogranin A (ELISA)


ELISA – Single Parameter Kits Catalog Details

Metanephrine Plasma ELISA Fast Track

BA E-8100 show more

Normetanephrine Plasma ELISA Fast Track

BA E-8200 show more
ELISA  –  Multi Parameter  Kits Catalog Details

2-MET Plasma ELISA Fast Track

BA E-8300 show more
RIA  –  Multi Parameter  Kits Catalog Details

2-MET Plasma RIA Fast Track

BA R-8300 show more

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